Reference Details
, .., , .., , .., , .., , .. and , .. (2006), " S27P -15 T IL3 ", , 2006, .8, 5-6: 731-736.

The purpose of our study was to investigate whether S27P and -15C T single nucleotide polymorphisms of the IL3 gene are associated with susceptibility to bronchial asthma (BA) in Russians living in the Central-Chernozem region of Russia. DNA samples obtained from 216 unrelated patients with A and 214 healthy controls were typed for S27P and -15C T polymorphisms in the IL3 gene by PCR-RFLP methods. A genderbased dimorphism in distribution of IL3 genotypes has been revealed for various clinical and pathogenetic BA variants. Both S27P and -15C T polymorphisms were found to be associated with general susceptibility to BA, predominantly in females (p=0,05). The studied genetic variants of IL3 gene were in strong linkage disequilibrium with each other (p<0,0001). Further studies are required to investigate phenotypic expression of S27P and - 15C T polymorphisms of IL3 gene and to clarify their roles in the pathogenesis of bronchial asthma.

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