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, Полоников А.В., , Иванов В.П., , Белугин Д.А., , Хорошая И.В., , Солодилова М.А. and , Панфилов В.И. (2006), "ИЗУЧЕНИЕ СВЯЗИ ДВУХ РАСПРОСТРАНЕННЫХ ПОЛИМОРФИЗМОВ S27P И -15С T ГЕНА IL3 С РАЗВИТИЕМ АЛЛЕРГИЧЕСКОЙ И НЕАЛЛЕРГИЧЕСКОЙ БРОНХИАЛЬНОЙ АСТМЫ У РУССКИХ ЖИТЕЛЕЙ ЦЕНТРАЛЬНОГО ЧЕРНОЗЕМЬЯ", Медицинская Иммунология, 2006, Т.8, № 5-6: стр 731-736. Abstract: The purpose of our study was to investigate whether S27P and -15C T single nucleotide polymorphisms of the IL3 gene are associated with susceptibility to bronchial asthma (BA) in Russians living in the Central-Chernozem region of Russia. DNA samples obtained from 216 unrelated patients with В A and 214 healthy controls were typed for S27P and -15C T polymorphisms in the IL3 gene by PCR-RFLP methods. A genderbased dimorphism in distribution of IL3 genotypes has been revealed for various clinical and pathogenetic BA variants. Both S27P and -15C T polymorphisms were found to be associated with general susceptibility to BA, predominantly in females (p=0,05). The studied genetic variants of IL3 gene were in strong linkage disequilibrium with each other (p<0,0001). Further studies are required to investigate phenotypic expression of S27P and - 15C T polymorphisms of IL3 gene and to clarify their roles in the pathogenesis of bronchial asthma. Keywords: бронхиальная астма, интерлейкин-3, ДНК-полиморфизм, анализ ассоциации, наследственная предрасположенность  Electronic Paper Link
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